HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus
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چکیده
4 Running title: HLA SNPs interact with HBV mutations in liver diseases 5 6 Qi Zhang, Jianhua Yin, Yuwei Zhang, Yang Deng, Xiaowei Ji, Yan Du, Rui Pu, 7 Yifang Han, Jun Zhao, Xue Han, Hongwei Zhang, and Guangwen Cao 8 9 a Department of Epidemiology, Second Military Medical University, Shanghai 200433, China 10 11 b Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second 12 Military Medical University, Shanghai 200433, China 13 14 c Division of Chronic Diseases, Center for Disease Control and Prevention of Yangpu District, 15 Shanghai 200090, China 16 17 Address correspondence to Guangwen Cao, [email protected]. 18 19 Q.Z. and J.Y. contributed equally to this work. 20 21 Word count: Main manuscript, 4319; Abstract, 250; Tables, 7; Figure, 1; References, 51. 22 23 JVI Accepts, published online ahead of print on 4 September 2013 J. Virol. doi:10.1128/JVI.02073-13 Copyright © 2013, American Society for Microbiology. All Rights Reserved.
منابع مشابه
HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations.
Genetic polymorphisms of HLA-DP have been associated with hepatitis B virus (HBV) persistence. We aimed to determine the effect of HLA-DP polymorphisms on the generation of HBV mutations and their interactions on the outcomes of HBV infection. rs3077, rs3135021, rs9277535, and rs2281388 were genotyped in 1,342 healthy controls, 327 HBV clearance subjects, and 2,736 HBV-positive subjects, includ...
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Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, genome-wide association studies have identified human leukocyte antigen (HLA)-DP polymorphisms (rs3077 and rs9277535) as a new chronic HBV infection susceptibility locus. Since then, the relationship between HLA-DP polymorphisms and v...
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Successful clearance of hepatitis B virus (HBV) is a promising event in which host's immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide association studies (GWAS) has confirmed polymorphisms in the human leukocyte antigen (HLA)-DP locu...
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BACKGROUND AND AIMS Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferr...
متن کاملHLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
BACKGROUND The roles of single-nucleotide polymorphisms (SNPs) at HLA-DP and IL28B loci on hepatitis B surface antigen (HBsAg) seroclearance in chronic hepatitis B (CHB) infection are unknown. METHODS We compared the HLA-DP (rs3077, rs9277378, rs3128917) and IL28B (rs12979860, rs8099917) polymorphisms of 203 CHB patients achieving spontaneous HBsAg seroclearance with 203 age- and sex-matched ...
متن کاملRole of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese
BACKGROUND AND AIMS The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. METHODS We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near ...
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تاریخ انتشار 2013